The Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish

• DOI: 10.1371/journal.pone.0143911
• Publication Date: 2015-12-03T18:39:27Z
• Authors: Angeliki Lyssimachou; Joana G. Santos; Ana André; Joana Soares; Daniela Lima; Laura Guimarães; C. Marisa R. Almeida; Catarina Teixeira; L. Filipe C. Castro; Miguel M. Santos
• Keywords: Lipogenesis

Recent findings indicate that different Endocrine Disrupting Chemicals (EDCs) interfere with lipid metabolic pathways in mammals and promote fat accumulation, a previously unknown site of action for these compounds. The antifoulant environmental pollutant tributyltin (TBT), which causes imposex gastropod snails, induces an "obesogenic" phenotype mammals, through the activation nuclear receptors retinoid X receptor (RXR) peroxisome proliferator-activated gamma (PPARγ). In teleosts, effects TBT on metabolism are poorly understood, particularly following exposure to low, concentrations. this context, present work shows zebrafish 10 50 ng/L (as Sn) from pre-hatch 9 months age alters body weight, condition factor, hepatosomatic index hepatic triglycerides gender dose related manner. Furthermore, modulated transcription key regulating factors enzymes involved adipogenesis, lipogenesis, glucocorticoid metabolism, growth development brain liver exposed fish, revealing sexual dimorphic latter. Overall, study model mammalian obesogen interferes triglyceride accumulation transcriptional regulation indentifies lipogenic profile fish as new target compound.