Specific Gene Loci of Clinical Pseudomonas putida Isolates

• DOI: 10.1371/journal.pone.0147478
• Publication Date: 2016-01-28T18:45:57Z
• Authors: Lázaro Molina; Zulema Udaondo; Estrella Duque; Matilde Fernández; Patricia Bernal; Amalia Roca; Jesús de la Torre; Juan Luis Ramos
• Keywords: Pseudomonas putida; Antitoxin; Pleiotropy

Pseudomonas putida are ubiquitous inhabitants of soils and clinical isolates this species have been seldom described. Clinical show significant variability in their ability to cause damage hosts because some them able modulate the host's immune response. In current study, comparisons between genomes different environmental strains P. were done identify genetic clusters shared by that not present isolates. We specific genes mostly on transposons, set exhibit high identity with found pathogens opportunistic pathogens. The prevalent isolates, absent related survival under oxidative stress conditions, resistance against biocides, amino acid metabolism toxin/antitoxin (TA) systems. This functions influence colonization within human tissues, since they avoid host response or enhance resistance. An depth bioinformatic analysis was also carried out exclusive each correlate phenotypical differences them, a secretion system type III-like one these strains, determinant pathogenicity Gram-negative bacteria.