Serum Creatinine Modifies Associations between Body Mass Index and Mortality and Morbidity in Prevalent Hemodialysis Patients

Male 2. Zero hunger Hip Fractures Science Q R Middle Aged Body Mass Index 3. Good health Survival Rate 03 medical and health sciences 0302 clinical medicine Cardiovascular Diseases Renal Dialysis Creatinine Prevalence Medicine Humans Kidney Failure, Chronic Female Biomarkers Research Article Aged
DOI: 10.1371/journal.pone.0150003 Publication Date: 2016-03-01T19:06:02Z
ABSTRACT
High body mass index (BMI) is paradoxically associated with better outcomes in hemodialysis (HD) patients. This study aimed to examine whether serum creatinine (Cr), a marker of muscle mass, could modify the association between BMI, and mortality morbidity prevalent HD patients.A retrospective was conducted using nationwide database from registry Japanese Society for Dialysis Therapy. A total 119,099 patients were selected (age: 65±12 years; median time on HD: 5.6 male: 62%), we examined basal BMI after 1-year period. Patients stratified either by into 4 groups or Cr levels 3 tertiles. Odds ratio (OR) [95% confidence interval] calculated multivariate logistic regression analysis.Higher did not predict higher mortality. However, when levels, risk cardiac death became significantly obese lowest both males (OR 2.82 [1.51-5.27], p<0.01) females 2.00 [1.03-3.90], p<0.05). The new cerebral infarction also male within tertile. In contrast, there lower cardiac, cerebrovascular, infection-related non-obese Cr. Higher related cardiovascular events hip fracture patients.The obesity paradox found be present only defined BMI. Decreased positively clinical poor all groups. Thus, irrespective evaluation important receiving regular HD.
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