Association of Opioids and Sedatives with Increased Risk of In-Hospital Cardiopulmonary Arrest from an Administrative Database

• DOI: 10.1371/journal.pone.0150214
• Publication Date: 2016-02-25T20:01:09Z
• Authors: Frank J. Overdyk; Oonagh Dowling; Joseph Marino; Jiejing Qiu; Hung-Lun Chien; Mary Erslon; Neil Morrison; Brooke Harrison; Albert Dahan; Tong J. Gan
• Keywords: Depression

Background While opioid use confers a known risk for respiratory depression, the incremental of in-hospital cardiopulmonary arrest, or resuscitation (CPRA) has not been studied. Our aim was to investigate prevalence, outcomes, and profile CPRA patients receiving opioids medications with central nervous system sedating side effects (sedatives). Methods A retrospective analysis adult inpatient discharges from 2008–2012 reported in Premier Database. Patients were grouped into four mutually exclusive categories: (1) sedatives, (2) only, (3) sedatives (4) neither nor sedatives. Results Among 21,276,691 discharges, 53% received without total 96,554 suffered (0.92 per 1000 hospital bed-days). who had an adjusted odds ratio 3.47 (95% CI: 3.40–3.54; p<0.0001) compared Opioids alone associated 1.81-fold 1.82-fold (p<0.0001 both) increase CPRA, respectively. In patients, locations intensive care (54%), general floor (25%), stepdown units (15%). Only 42% survived only 22% discharged home. Opioid mean increased lengths stay 7.57 days costs $27,569. Conclusions are independent additive factors CPRA. The impact sparing analgesia, reduced sedative use, better monitoring on incidence deserves further study.