Association between Concentrations of Metals in Urine and Adult Asthma: A Case-Control Study in Wuhan, China

• DOI: 10.1371/journal.pone.0155818
• Publication Date: 2016-05-18T17:37:04Z
• Authors: Xiji Huang; Jungang Xie; Xiuqing Cui; Yun Zhou; Xiaojie Wu; Wei Lu; Yan Shen; Jing Yuan; Weihong Chen
• Keywords: Adult; Male; China; Science; Q; R; Middle Aged; 01 natural sciences; Asthma; 3. Good health; Metals; Medicine; Humans; Female; Research Article; Aged; 0105 earth and related environmental sciences

Background Several metals have been reported to be associated with childhood asthma. However, the results on relationships between and risk of asthma are inconclusive, research adult in Chinese general population is rare. Objectives To investigate potential associations levels urinary Methods A case-control study 551 cases gender- age-matched controls was conducted Wuhan, China. Demographic information obtained, lung function assessed. The concentrations 22 were measured by inductively coupled plasma mass spectrometry. Results After adjusting for other metalsand covariates, cadmium, molybdenum, chromium, copper, uranium selenium positively asthma, odds ratios (95% CI) 1.69 (1.00, 2.85), 3.76 (2.30, 6.16), 4.89 (3.04, 7.89), 6.06 (3.27, 11.21), 6.99 (4.37, 11.19) 9.17 (4.16, 20.21), respectively. By contrast, lead, barium, iron, zinc, nickel, manganese rubidium negatively 0.48 (0.29, 0.80), 0.44 (0.27, 0.71), 0.41 (0.26, 0.64), 0.40 (0.24, 0.66), 0.30 (0.22, 0.41), 0.23 (0.14, 0.39) 0.07 (0.03, 0.15), When comparing different subgroups those matched controls, above 13 prevalence nearly same. Conclusions Our suggested that adults selenium, uranium, manganese, rubidium, barium lead. Additional larger populations regions required support our findings.