Epidemiological, Clinical and Antiretroviral Susceptibility Characterization of Human Immunodeficiency Virus Subtypes B and Non-B in Pernambuco, Northeast Brazil

• DOI: 10.1371/journal.pone.0155854
• Publication Date: 2016-05-24T17:31:51Z
• Authors: Kledoaldo Lima; Élcio de Souza Leal; Ana Maria Salusti...; Daniela Medeiros ...; Luzidalva Barbosa...; Sirleide Pereira ...; Heloísa Ramos Lac...
• Keywords: Adult; Male; Anti-HIV Agents; Science; HIV Infections; 03 medical and health sciences; Drug Resistance, Viral; Humans; Syphilis; Phylogeny; 0303 health sciences; Coinfection; Q; R; Viral Load; Hepatitis B; Hepatitis C; 3. Good health; pol Gene Products, Human Immunodeficiency Virus; Mutation; HIV-1; Medicine; Female; Brazil; Research Article

Background HIV-1 diversity causes important differences in the virus' biological properties and their interactions with hosts, such as cell tropism, responses to antiretroviral therapy, drug-resistance, disease progression. Objectives We evaluated interrelationship of phylogenetic inference epidemiological laboratory data for isolates circulating Pernambuco, Northeast Region—Brazil. Study design A total 168 pol sequences were analysed, 64 obtained from 2002–2003, 104, 2007–2009. Socio-demographic, clinical, behavioural medical records. Laboratory testing enabled determination recent infections co-infections HBV, HCV, HTLV, or syphilis. Surveillance drug-resistance mutation analysis susceptibility profiling performed using HIV Drug-Resistance Database. Results non-B was associated female, lower education, viral loads, higher T counts mean. Frequencies co-infection HIV-HBV, HIV-HCV, HIV-syphilis 27.8% (95% CI: 19.8–37.7), 1.04% 0.05–5.00) 14.7% 8.6–23.0), respectively. Drug-resistant mutations rate 2.98% 1.10–6.47). HIV-HBV subtype B men who have sex (MSM), loads males. MSM status, Conclusions Data showed importance molecular characterisations epidemic its relation clinical characteristics population, well association other infectious diseases, so they can effort improve preventive measures health services more information about progress effects Northeastern–Brazil.