Preoperative Multiparametric Magnetic Resonance Imaging Predicts Biochemical Recurrence in Prostate Cancer after Radical Prostatectomy

• DOI: 10.1371/journal.pone.0157313
• Publication Date: 2016-06-23T14:04:01Z
• Authors: Richard Ho; Mohummad M. Siddiqui; Arvin K. George; Thomas Frye; Amichai Kilchevsky; Michele Fascelli; Nabeel A. Shakir; Raju Chelluri; Steven F. Abboud; Annerleim Walton-...; Sandeep Sankineni; Maria J. Merino; Baris Turkbey; Peter L. Choyke; Bradford J. Wood; Peter A. Pinto
• Keywords: Biochemical recurrence; Nomogram; breakpoint cluster region

Objectives To evaluate the utility of preoperative multiparametric magnetic resonance imaging (MP-MRI) in predicting biochemical recurrence (BCR) following radical prostatectomy (RP). Materials/Methods From March 2007 to January 2015, 421 consecutive patients with prostate cancer (PCa) underwent MP-MRI and RP. BCR-free survival rates were estimated using Kaplan-Meier method. Cox proportional hazards models used identify clinical variables predictive BCR. Logistic regression was performed generate a nomogram predict three-year BCR probability. Results Of total cohort, 370 met inclusion criteria 39 (10.5%) experiencing On multivariate analysis, prostate-specific antigen (PSA) (p = 0.01), biopsy Gleason score 0.0008), suspicion 0.03), extracapsular extension on 0.03) significantly associated time A integrating these factors at three years after RP demonstrated c-index 0.84, outperforming value PSA alone (c-index 0.74, p 0.02). Conclusion The addition standard improves prediction post-prostatectomy PCa cohort. This could serve as valuable tool support decision-making moderate high-risk cancers.