Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model

• DOI: 10.1371/journal.pone.0160882
• Publication Date: 2016-08-08T17:35:23Z
• Authors: Mako Yamamoto; Ming Zhao; Yukihiko Hiroshima; Yong Zhang; Elizabeth Shurell; Fritz C. Eilber; Michael Bouvet; Makoto Noda; Robert M. Hoffman
• Keywords: Salmonella enterica; Nude mouse

Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing highly and selectively colonized the PDOX significantly suppressed tumor growth (p = 0.021). The combination of cisplatinum (CDDP), both at low-dose, also (P 0.001). has future clinical potential for chemotherapy with CDDP melanoma, highly-recalcitrant cancer.