Outlining the Ancestry Landscape of Colombian Admixed Populations

• DOI: 10.1371/journal.pone.0164414
• Publication Date: 2016-10-13T17:54:40Z
• Authors: Humberto Ossa; Juliana Aquino; Rui Pereira; Adriana Ibarra; Rafael H Ossa; Luz Adriana Pérez; Juan David Granda; Maria Claudia Lattig; Helena Groot; Elizeu Fagundes d...; Leonor Gusmão
• Keywords: Indel; Genetic admixture; Ancestry-informative marker; Founder effect; Population Genetics

The ancestry of the Colombian population comprises a large number well differentiated Native communities belonging to diverse linguistic groups. In late fifteenth century, process admixture was initiated with arrival Europeans, and several years later, Africans also became part population. Therefore, genepool current results from Americans, Europeans Africans. This occurred differently in each region country, producing clearly stratified Considering importance substructure both clinical forensic genetics, we sought investigate compare patterns genetic Colombia by studying samples non-Native populations living its 5 continental regions: Andes, Caribe, Amazonia, Orinoquía, Pacific regions. For this purpose, 46 AIM-Indels were genotyped 761 non-related individuals populations. Previously published genotype data 214 Natives five used for comparisons. Significant differences observed between populations, among different regions ethnic highest African ancestry, Amazonia harboured Andean Orinoquían showed proportion European ancestry. further sub-divided into 6 sub-regions: North East, Central West, South West East. Among these regions, significantly lower than other Hardy-Weinberg equilibrium variance values within potential stratification