Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism

• DOI: 10.1371/journal.pone.0164530
• Publication Date: 2016-10-31T17:35:02Z
• Authors: Zhiyuan Tang; Xudong Wang; Jianfei Huang; Xiaoyu Zhou; Hao Xie; Qilin Zhu; Minjie Huang; Songshi Ni
• Keywords: Pathogenesis

Acute pulmonary thromboembolism (PTE) refers to the obstruction of thrombus in artery or its branches. Recent studies have suggested that PTE-induced endothelium injury is major physiological consequence PTE. And it reasonal use stratify disease severity. According massive morphologic and histologic findings, rabbit models could be applied closely mimic human PE. Genomewide gene expression profiling has not been attempted In this study, we determined accuracy autologous PTE model for disease, then array identify changes arteries under potential molecular biomarkers signaling pathways We detected 1343 genes were upregulated 923 downregulated rabbits. The several (IL-8, TNF-α, CXCL5) with functional importance further confirmed transcript protein levels. most significantly differentially regulated related inflammation, immune cardiovascular diseases. Totally 87 up-regulated inflammatory genes. conclude extend understanding pathogenesis at level. Our study provides fundamental framework future clinical research on PTE, including identification prognosis therapeutic targets