Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

• DOI: 10.1371/journal.pone.0165609
• Publication Date: 2016-10-31T17:36:44Z
• Authors: Noriaki Arakawa; Hiroshi Kobayashi; Naohiro Yonemoto; Yusuke Masuishi; Yoko Ino; Hiroshi Shigetomi; Naoto Furukawa; Norihisa Ohtake; Yohei Miyagi; Fumiki Hirahara; Hisashi Hirano; Etsuko Miyagi
• Keywords: Adult; Science; Carcinoma, Ovarian Epithelial; 03 medical and health sciences; 0302 clinical medicine; Biomarkers, Tumor; Humans; Neoplasms, Glandular and Epithelial; Menstrual Cycle; Aged; Glycoproteins; Neoplasm Staging; Aged, 80 and over; Ovarian Neoplasms; Q; R; Age Factors; Middle Aged; Prognosis; 3. Good health; CA-125 Antigen; Preoperative Period; Medicine; Female; Neoplasm Grading; Genital Diseases, Female; Research Article; Adenocarcinoma, Clear Cell

There is currently no reliable serum biomarker for ovarian clear cell carcinoma (CCC), a highly lethal histological subtype of epithelial cancer (EOC). Previously, using proteome-based approach, we identified tissue factor pathway inhibitor 2 (TFPI2) as candidate CCC. In this study, sought to evaluate the clinical diagnostic performance TFPI2 in preoperative prediction CCC.Serum levels were measured samples from retrospective training set consisting patients with benign and borderline tumors, EOC subtypes, uterine diseases. Via receiver operating characteristic (ROC) analyses, compared that CA125 discrimination CCC other patient groups. The observed performances examined prospective validation set.The 268-patient included 29 Unlike CA125, which was also elevated endometriosis several specifically only patients, consistent mRNA expression pattern tumor tissues. area under ROC curve (AUC) obviously higher than diseases (AUC = 0.891 versus 0.595). Applying cut-off value 280 pg/mL, could distinguish early-stage (FIGO I II) 72.2% sensitivity, 93.3% specificity, 88.8% accuracy. Similar results confirmed an independent 156-patient set.TFPI2 useful diagnosis