Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

• DOI: 10.1371/journal.pone.0166845
• Publication Date: 2016-11-23T20:00:41Z
• Authors: Karla Reichert; Helison Rafael Pe...; Anali Galluce Torina; Daniela Diógenes ...; Andrei Carvalho S...; Karlos Alexandre ...; Lindemberg da Mot...; Pedro Paulo Marti...; Orlando Petrucci
• Keywords: Ventricular remodeling; Myocardial fibrosis; TIMP1; Cardiac Fibrosis

Therapeutic strategies that modulate ventricular remodeling can be useful after acute myocardial infarction (MI). In particular, statins may exert effects on molecular pathways involved in collagen metabolism. The aim of this study was to determine whether treatment with atorvastatin for 4 weeks would lead changes metabolism and a rat model MI.Male Wistar rats were used study. MI induced by ligation the left anterior descending coronary artery (LAD). Animals randomized into three groups, according treatment: sham surgery without LAD (sham group, n = 14), followed 10mg atorvastatin/kg/day (atorvastatin 24), or saline solution (control 27). After weeks, hemodynamic characteristics obtained pressure-volume catheter. Hearts removed, ventricles subjected histologic analysis extents fibrosis deposition, as well myocyte cross-sectional area. Expression levels mediators inflammation also assessed.End-diastolic volume, fibrotic content, area significantly reduced compared control group. Atorvastatin modulated expression proteins related metabolism, including MMP1, TIMP1, COL I, PCPE, SPARC, remote infarct regions. had anti-inflammatory effects, indicated lower TLR4, IL-1, NF-kB p50.Treatment able attenuate dysfunction, fibrosis, hypertrophy rats, perhaps part through inflammation. limiting ischemic events.