Effects of dietary beef, pork, chicken and salmon on intestinal carcinogenesis in A/J Min/+ mice

• DOI: 10.1371/journal.pone.0176001
• Publication Date: 2017-04-20T17:57:53Z
• Authors: Christina Steppeler; Marianne Sødring; Bjørg Egelandsdal; Bente Kirkhus; Marije Oostindjer; Ole Alvseike; Lars Erik Gangsei; Ellen-Margrethe H...; Fabrice Pierre; Jan Erik Paulsen
• Keywords: TBARS; Red meat; Thiobarbituric acid; White meat; Lipid Oxidation

The International Agency for Research on Cancer has classified red meat as "probably carcinogenic to humans" (Group 2A). In mechanistic studies exploring the link between intake of and CRC, heme iron, pigment meat, is proposed play a central role catalyzer luminal lipid peroxidation cytotoxicity. present work, novel A/J Min/+ mouse was used investigate effects dietary beef, pork, chicken, or salmon (40% muscle food (dry weight) 60% powder diet) Apc-driven intestinal carcinogenesis, from week 3–13 age. Muscle diets did not differentially affect carcinogenesis in colon (flat ACF tumors). small intestine, resulted lower tumor size load than terrestrial animals (beef, pork chicken), while no differences were observed white (chicken) (pork beef). Additional results indicated that related n-6 polyunsaturated fatty acids, formation products (thiobarbituric acid reactive substances, TBARS), cytotoxic fecal water Apc-/+ cells. Notably, amount reaching appeared be relatively low this study. greatest induced by reference diet RM1, underlining importance basic experimental CRC. study mice does support hypothesis carcinogenesis.