Increase in serum albumin concentration is associated with prediabetes development and progression to overt diabetes independently of metabolic syndrome

• DOI: 10.1371/journal.pone.0176209
• Publication Date: 2017-04-21T13:27:23Z
• Authors: Ji Eun Jun; Seung-Eun Lee; You-Bin Lee; Jae Hwan Jee; Ji Cheol Bae; Sang-Man Jin; Kyu Yeon Hur; Moon-Kyu Lee; Jae Hyeon Kim
• Keywords: Prediabetes; Serum Albumin; Impaired fasting glucose; Quartile

Aim Serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). We sought to investigate whether baseline serum change in could be independent risk factors for prediabetes subjects without MetS. further examined the effect of on progression overt who developed prediabetes. Methods Among 10,792 participants MetS consecutively underwent yearly health check-ups over six years, 9,807 incident were enrolled this longitudinal retrospective study. The developing (impared fasting glucose or hemoglobin A1c) was analyzed according percent using Cox regression analysis. Serial changes measured from one year before diagnosis, then time diagnosis final follow-up. Results A total 4,398 cases during 35,807 person-years (median 3.8 years). hazard ratio decreased as (quartiles per 1%) increased a crude fully adjusted model. However, itself not prediabetic risk. levels kept increasing until end follow-up returned normal glycemic status, whereas these measures did diabetes. at highest group, compared stationary (p = 0.014) groups 0.009). Conclusions Increase might protect against early deterioration even