Factors associated with acquired Anti IFN- γ autoantibody in patients with nontuberculous mycobacterial infection

• DOI: 10.1371/journal.pone.0176342
• Publication Date: 2017-04-24T13:24:28Z
• Authors: Pakpoom Phoompoung; Nasikarn Ankasekw...; Manop Pithukpakorn; Suporn Foongladda; Pinklow Umrod; Bhoom Suktitipat; Surakameth Mahasi...; Sasisopin Kiertib...; Yupin Suputtamongkol
• Keywords: Nontuberculous Mycobacteria; Univariate analysis

The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors this remain unknown.We performed unmatched case control study among NTM diseases diagnosed and treated at Siriraj Hospital, Bangkok, Thailand. Anti-IFN was detected by enzyme-linked immunosorbent assay (ELISA) method. Cases detectable anti autoantibody. Controls randomly selected from those undetectable Data both groups including demographic data, presentation, laboratory results, other HLA genotypes collected. Univariate multivariate analyses identify independent for syndrome.70 cases (mean age 50 ± 11 years) 70 controls 58 18 enrolled into study. Mycobacterial abscessus most common pathogen found (72.9% 41.4% respectively). disease significantly more (92.9%) than (14.3%, p<0.001). Binary logistic regression analysis showed that previous OIs (adjusted OR14.87, 95% CI 2.36-93.86), birthplace outside Central region OR 19.19, 3.86-95.35), lack comorbidities lead immunosuppression, such as HIV or diabetes mellitus 23.68, 4.01-139.94), presence DRB1*15/16 153.28, 16.87-139.88) syndrome.Patients are almost always negative. Most these presented generalized lymphadenitis often reactive skin lesions. Factors HLA-DRB1 DQB1 alleles, history without comorbidity leads immunosuppression. Further studies needed better understand associations improve treatment outcome.