OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices

• DOI: 10.1371/journal.pone.0177059
• Publication Date: 2017-05-10T14:26:48Z
• Authors: Marion R. Munk; Helena Giannakaki...; Lieselotte Berger; Wolfgang Huf; Andreas Ebneter; Sebastian Wolf; Martin S. Zinkern...
• Keywords: Grading (engineering)

Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina nineteen healthy volunteers were scanned with OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). device-software generated en-face OCT-A images superficial (SCP) deep capillary plexuses (DCP) evaluated scored by 3 independent retinal imaging experts. SCP vessel density was assessed using Angiotool-software. After inter-grader reliability assessment, consensus grading performed modules ranked based on their scoring. Results There no significant difference in among (Zeiss 48.7±4%, 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). numbers discernible vessel-bifurcations differed significantly each module 2±0.9 bifurcations, 2.5±1.2, 1.3±0.7 0.5±0.6, p≤0.001). ranking depending parameter. In overall ranking, superior 90% better than median (Bonferroni corrected p-value 0.04). 60%, 40% 10%, however these differences not statistically significant. Conclusion Each had particular strengths, which differentiated it from competitors.