The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants

• DOI: 10.1371/journal.pone.0178032
• Publication Date: 2017-05-30T17:41:13Z
• Authors: Annika Hartz; Julia Pagel; Alexander Humberg; Michael Preuss; Lena Schreiter; Jan Rupp; Julia Figge; Christian M. Karsten; Peter Nürnberg; Egbert Herting; Wolfgang Göpel; Christoph Härtel
• Keywords: 0301 basic medicine; Polymorphism, Genetic; Science; Q; R; Infant, Newborn; Infections; Mannose-Binding Lectin; 3. Good health; Cohort Studies; 03 medical and health sciences; Mannose-Binding Lectins; Medicine; Humans; Infant, Very Low Birth Weight; Metabolism, Inborn Errors; Research Article

Studies on the influence of mannose-binding lectin (MBL) deficiency infection susceptibility in preterm infants have yielded controversial results. We investigated association genotype-based MBL levels with outcome very-low-birth weight (VLBWI).We genotyped 3 genetic variants MBL2 (rs1800450, rs1800451, rs5030737) 6878 VLBWI. plasma were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary was effect blood-culture proven and clinical sepsis during primary stay hospital. also evaluated burden within 24 months after discharge.We found no between risk whole cohort. Infants without measurable born 32 0/7 to 36 6/7 weeks gestation, however, had a higher rate Gram-negative than reduced levels. In follow-up investigation at (n = 1070 infants), suffered more frequently from stomatitis urinary tract infection.In large cohort VLBWI major impact unless children gestation.