Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease

• DOI: 10.1371/journal.pone.0179399
• Publication Date: 2017-06-15T21:16:03Z
• Authors: Pai-Yi Chiu; Chein-Wei Wang; Chun-Tang Tsai; Shin-Hua Li; Chih-Li Lin; Te-Jen Lai
• Keywords: Depression; Anhedonia; Clinical Dementia Rating

Background Depression is highly associated with dementia, and this study will compare the frequencies, severity, symptoms of depression between dementia Lewy bodies (DLB) Alzheimer's disease (AD). Methods Frequency was determined according to DSM-IV criteria for major or National Institute Mental Health in AD (NIMH-dAD). Severity were assessed using Hamilton Rating Scale, Cornell Scale Dementia, subscale Neuropsychiatric Inventory. The rates depressive compared DLB. Results A total 312 patients investigated (AD/DLB = 241/71). frequency significantly higher (p 0.017) DLB (19.7%) than (8.7%). not reproduced by NIMH-dAD (DLB: 43.7%: 33.2%; p 0.105). severity < 0.001) Dementia 0.001). Among symptoms, pervasive anhedonia had highest odds ratio AD. Conclusion This first investigate Our shows that co-morbid more frequent Pervasive greatest value differential diagnosis