Quantitative assessment of simultaneous F-18 FDG PET/MRI in patients with various types of hepatic tumors: Correlation between glucose metabolism and apparent diffusion coefficient

• DOI: 10.1371/journal.pone.0180184
• Publication Date: 2017-07-03T13:32:30Z
• Authors: Eunjung Kong; Kyung Ah Chun; Ihn Ho Cho
• Keywords: Standardized uptake value

Metabolism and water diffusion may have a relationship or an effect on each other in the same tumor. Knowledge of their could expand understanding tumor biology serve field oncologic imaging. This study aimed to evaluate between metabolism diffusivity hepatic tumors using simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) system with F-18 fluorodeoxyglucose (FDG) reveal metabolic diffusional characteristics type tumor.Forty-one patients (mean age 63 ± 13 years, 31 male) (18 hepatocellular carcinoma [HCC], six cholangiocarcinoma [CCC], 10 metastatic tumors, one neuroendocrine malignancy, benign lesions) underwent FDG PET/MRI before treatment. Maximum standard uptake (SUVmax) values from PET apparent coefficient (ADC) diffusion-weighted images were obtained for relationships examined. We also investigated difference SUVmax ADC tumor.SUVmax showed negative correlation (r = -0.404, p 0.009). The median was 3.22 HCC, 6.99 CCC, 6.30 1.82 lesions. 1.039 × 10-3 mm/s2 1.148 0.876 1.323 higher than lesions (p 0.023). Metastatic had lower CCC 0.039) 0.004). HCC lesions, suggestive trend 0.06).Our results indicate that is negatively correlated group has different characteristics. Evaluation by be helpful