Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

• DOI: 10.1371/journal.pone.0180476
• Publication Date: 2017-06-29T17:56:46Z
• Authors: Juan Wang; Wenji Hu; Lanzhou Li; Xinping Huang; Yange Liu; Di Wang; Lirong Teng
• Keywords: Malondialdehyde; Inonotus obliquus

This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors oxidative stress in a mouse model streptozotocin (STZ)-induced diabetes. Four weeks administration metformin (120 mg/kg) IO1-4 (50%-80% alcohol precipitation), or IO5 (total 80% precipitation) at doses 50 mg/kg reverses abnormal changes bodyweights fasting blood glucose levels diabetic mice. IOs significantly increased insulin pyruvate kinase serum, improved synthesis glycogen, especially for IO5. restored disturbed serum superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde. The down-regulation interleukin-2 receptor, matrix metalloproteinase-9, enhancement mice were attenuated by IOs. Histologic morphology examinations showed that repaired damage kidney tissues, inhibited infiltrate extracellular deposit injuries Compared with untreated mice, decreased expression phosphor-NF-κB kidneys. These results show treatment renal injure STZ-induced possibly through modulation factors. provide valuable evidences support use I. as hypoglycemic functional food and/or medicine.