Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion

• DOI: 10.1371/journal.pone.0182187
• Publication Date: 2017-08-07T13:27:34Z
• Authors: Muyideen K. Tijani; Oluwatoyin A. Bab...; Alex B. Odaibo; Chiaka I. Anumudu; Adanze O. Asinobi; Olajumoke A. More...; Michael C. Asuzu; Christine Langer; Linda Reiling; James G. Beeson; Mats Wahlgren; Roseangela I. Nwuba; Kristina E. M. Pe...
• Keywords: Humoral immunity

Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression utilization by to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living an endemic region Nigeria over almost one year against these vaccine candidates. Antibody levels EBA140, EBA175, EBA181, PfRh2, PfRh4, MSP2, were measured ELISA. also used parasites with disrupted EBA175 EBA181 genes show all targets of invasion However, antigenic not stable changed substantially time most individuals, independent age. Antibodies ELISA varied within between the PfRh2 MSP2 declined more rapidly younger (≤15 years) compared older (>15). The breadth high antibody responses was influenced age than frequency infection. High associated a response, which could indicate during long process formation immunity, many changes only but functional needed. This is finding understanding natural immunity malaria, essential for making efficacious vaccine.