Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status

• DOI: 10.1371/journal.pone.0183136
• Publication Date: 2017-08-14T19:31:24Z
• Authors: Elise Kaspi; Diane Frankel; Julien Guinde; Sophie Perrin; Sophie Laroumagne; Andrée Robaglia-S...; Kevin Ostacolo; Karim Harhouri; Rachid Tazi-Mezalek; Joelle Micallef; Hervé Dutau; Pascale Tomasini; Annachiara De San...; Nicolas Lévy; Pierre Cau; Philippe Astoul; Patrice Roll
• Keywords: LMNA; Nuclear lamina

The type V intermediate filament lamins are the principal components of nuclear matrix, including lamina. Lamins divided into A-type and B-type, which encoded by three genes, LMNA, LMNB1, LMNB2. alternative splicing LMNA produces two major lamins, lamin A C. Previous studies have suggested that involved in cancer development progression. been proposed as biomarkers for diagnosis, prognosis, and/or follow-up. aim present study was to investigate cells from metastatic pleural effusions using immunofluorescence, western blotting, flow cytometry. In a sub-group lung adenocarcinomas, we found reduced expression but not reduction correlated with loss epithelial membrane antigen (EMA)/MUC-1, an marker is mesenchymal transition (EMT). Finally, inversely number sites WHO Performance status, association pleural, bone localizations more frequent when reduced. conclusion, low C could represent actor metastasis, associated EMT account pejorative factor poor status.