Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system

• DOI: 10.1371/journal.pone.0183314
• Publication Date: 2017-08-18T13:25:02Z
• Authors: Sônia de Fátima Soto; Juliana Oliveira ...; Guilherme D’April...; Karen Lucasechi L...; Mariana Matera Veras; Ivone Braga de Ol...; Regiane Machado d...; Isac de Castro; Luzia Naôko Shino...; Paulo Hilário Nas...; Joel C. Heimann
• Keywords: Trophoblast

Female Wistar rats were exposed to filtered air (F) or concentrated fine particulate matter (P) for 15 days. After mating, the divided into four groups and again F P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic 19, placenta was collected. The placental structure, protein gene expression TGFβ1, VEGF-A, its receptor Flk-1 RAS evaluated by indirect ELISA quantitative real-time PCR.Exposure decreased mass, size, surface area as well VEGF-A content. In maternal portion placenta, angiotensin II (AngII) receptors AT1 (AT1R) AT2 (AT2R) in PF PP groups. fetal AngII AT2R decreased, but AT1R increased FP group. lower group than FF group.Exposure pollutants before and/or during pregnancy alters some characteristics indicating a possible impairment trophoblast invasion angiogenesis with consequences maternal-fetal interaction, such limitation nutrition growth.