Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses

• DOI: 10.1371/journal.pone.0183791
• Publication Date: 2017-09-22T17:33:52Z
• Authors: Mathieu Gayda; Vincent Gremeaux; Louis Bherer; Martin Juneau; Joffrey Drigny; Olivier Dupuy; Gabriel Lapierre; Véronique Labelle; Annik Fortier; Anil Nigam
• Keywords: Impedance cardiography

Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions otherwise healthy, asymptomatic individuals. We sought assess function a stable coronary heart disease (CHD) sample and its relationship cerebral oxygenation-perfusion, cardiac hemodynamic responses, [Formula: see text] peak compared age-matched young healthy control subjects. Twenty-two controls (YHC), 20 old (OHC) 25 patients with CHD were recruited. Cognitive assessment included short term-working memory, perceptual abilities, processing speed, inhibition flexibility long-term verbal memory. Maximal cardiopulmonary (gas exchange analysis), (impedance cardiography) left frontal oxygenation-perfusion (near-infra red spectroscopy) measured during after maximal incremental ergocycle test. Compared OHC CHD, YHC had higher peak, index (CI max), (ΔO2 Hb, ΔtHb: recovery) (for all items) (P<0.05). OHC, lower CI max, (during memory max related (P<0.005). Cerebral (exercise) was Stable have worse function, similar oxygenation/perfusion but reduced one recovery vs. their aged-matched counterparts. In the sample, correlated oxygenation-perfusion.