The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

• DOI: 10.1371/journal.pone.0185114
• Publication Date: 2017-10-03T17:36:58Z
• Authors: Steffen E. Petersen; Mihir M. Sanghvi; Nay Aung; Jackie A. Cooper; José Miguel Paiva; Filip Zemrak; Kenneth Fung; Elena Lukaschuk; Aaron M. Lee; Valentina Carapella; Young Jin Kim; Stefan K. Piechnik; Stefan Neubauer
• Keywords: Subclinical infection

The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure function. This aimed quantify the association between modifiable risk factors cardiac morphology function in individuals without known disease.Age, sex, ethnicity (non-modifiable) systolic blood pressure, diastolic smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important factors. Multivariable regression models built ascertain on left (LV), right (RV), (LA) (RA) CMR parameters.4,651 participants included analysis. All had significant effects differing parameters. BMI was factor most consistently associated with subclinical changes parameters, particularly relation higher LV (+8.3% per SD [4.3 kg/m2], 95% CI: 7.6 8.9%), (EDV: +4.8% SD, 4.2 5.4%); ESV: +4.4% 3.5 5.3%), RV +5.3% 4.7 5.9%; +5.4% 4.5 6.4%) LA maximal (+8.6% 7.4 9.7%) volumes. Increases SBP (+6.8% 5.9 7.7%), +4.5% 3.6 5.4%; +2.0% 0.8 3.3%) presence diabetes or cholesterol resulted smaller volumes lower ejection fractions.Modifiable are alterations all four chambers. pressure affecting parameters be linked adverse outcomes.