Gold nanorod reshaping in vitro and in vivo using a continuous wave laser

• DOI: 10.1371/journal.pone.0185990
• Publication Date: 2017-10-18T13:41:16Z
• Authors: David Harris-Birtill; Mohan Singh; Yu Zhou; Anant Shah; Pakatip Ruenraroe...; Maria Elena Gallina; George B. Hanna; Anthony E. G. Cass; Alexandra E. Porter; Jeffrey Bamber; Daniel S. Elson
• Keywords: Nanorod; Photothermal effect; Continuous wave

Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures contrast agents and catalysts photothermal therapy. Their optical absorption spectral peak wavelength is determined by their size shape. Photothermal therapy using GNRs typically established near infrared light this allows sufficient penetration into the tumour matrix. Continuous wave (CW) lasers most commonly applied source of irradiation on It perceived that large tumours may require fractionated or prolonged irradiation. However true efficacy repeated protracted CW sites original sample remains unclear. In study spectroscopy transmission electron microscopy used to demonstrate reshape both vitro vivo after irradiation, reduces efficiency. These changes were sustained throughout beyond initial period resulting from a blue-shift considerable diminution GNRs. Solid subcutaneous immunodeficient BALB/c mice subjected analysed with pre- post-CW laser This phenomenon thermally induced GNR reshaping can occur at relatively low bulk temperatures, well below melting point gold. Photoacoustic monitoring also evaluated potential clinical aid determine during Aggregation particles was coincidentally observed following would further diminish subsequent capacity irradiated thus sequential applications will not confer any additional effect due significant attenuations properties primary