High-performance wireless powering for peripheral nerve neuromodulation systems

• DOI: 10.1371/journal.pone.0186698
• Publication Date: 2017-10-24T18:09:50Z
• Authors: Yuji Tanabe; John S. Ho; Jiayin Liu; Song-Yan Liao; Zhe Zhen; Stephanie Hsu; Chika Shuto; Zi-Yi Zhu; Andrew Ma; Christopher Vassos; Peter Chen; Hung Fat Tse; Ada S. Y. Poon
• Keywords: Neuromodulation; Vagus Nerve Stimulation

Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating wide range disorders. Wireless powering could enable long-term operation these devices, but achieving high performance miniaturized and deeply placed remains technological challenge. We report the integration wireless system in soft neuromodulation device (15 mm length, 2.7 diameter) demonstrate (about 10%) during vivo stimulation vagus nerve porcine animal model. The increased enabled by generation focused circularly polarized field that enhances efficiency provides immunity to polarization misalignment. These characteristics establish clinical potential emerging therapies based on neuromodulation.