Wound healing properties of Copaifera paupera in diabetic mice

• DOI: 10.1371/journal.pone.0187380
• Publication Date: 2017-10-31T14:28:03Z
• Authors: Jorge Luis Amorim; Janaína de Barros...; Ana Claudia Ferna...; Eliane Gouvêa de ...; Célia Palmero; Maria Athana MPal...; Aline de Souza Ramos; José Luiz Pinto F...; Jefferson Rocha d...; Claudia Farias Be...; Silvia Luciane Basso; Luiz Eurico Nasci...; Patricia Dias Fer...
• Keywords: Oleoresin

Copaifera oleoresin is one of the most used natural products in popular medicine all over world. Among other effects (i.e., anti-inflammatory, antinociceptive, microbicidal) well-known its wound healing capacity. However, mechanism by which presents effect still not clear. In this study, our aim was to evaluate capacity obtained from paupera, action and identify major components. For these purposes, diabetic Swiss Webster mice were topically treated with (100, 150 or 200 mg/kg) for 14 consecutive days after an excision performed back mice. Cytokines, retraction histological evaluation conducted at 3, 7 10 (for cytokines); 0, 7, retraction); evaluation). Our data indicate that significantly reduced production MCP-1 TNF-α post-excision increased IL-10 both days. All treatments demonstrated similar higher collagenase-treated Histological evaluations dose treatment resulted better resolution closure levels collagen deposition indexes re-epithelialization even when compared group. The paupera it than ointment routinely improvement healing, suggesting as option use patients.