Loss of chromosome Y in blood, but not in brain, of suicide completers

• DOI: 10.1371/journal.pone.0190667
• Publication Date: 2018-01-04T14:33:57Z
• Authors: Atsushi Kimura; Akitoyo Hishimoto; Ikuo Otsuka; Satoshi Okazaki; Shuken Boku; Tadasu Horai; Takeshi Izumi; Motonori Takahashi; Yasuhiro Ueno; Osamu Shirakawa; Ichiro Sora
• Keywords: 0301 basic medicine; Chromosomes, Human, Y; Science; Q; R; Brain; 3. Good health; Suicide; 03 medical and health sciences; Medicine; Humans; Chromosome Deletion; Research Article

Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology suicide. Recent studies found an aberrant loss Y (LOY) in various diseases; however, no study has investigated whether there is association between LOY and The purpose this was determine occurs men who Our consisted 286 male Japanese subjects comprised 140 completers without severe physical illness (130 post-mortem samples peripheral blood 10 brains) 146 age-matched control from healthy individuals 16 brains). measured as Y/chromosome X ratio fluorescent signal co-amplified short sequences Y-X homologous amelogenin genes (AMELY AMELX). Regression analyses showed significantly more frequent controls (odds = 3.50, 95% confidence interval 1.21–10.10), but not dorsolateral prefrontal cortex (DLPFC) region brain. Normal age-dependent (r -0.353, p < 0.001), seen -0.119, 0.177). DLPFC tissue had (B -0.002, 0.015), independent phenotype. To our knowledge, first demonstrating associated with completion. In addition, findings are also indicate occur only blood, specific brain regions.