Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness

• DOI: 10.1371/journal.pone.0193801
• Publication Date: 2018-03-21T17:32:54Z
• Authors: Chrysovalantis Vo...; Triantafyllos Sty...
• Keywords: Tranilast

Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines large part tumor biochemical mechanical microenvironment. Additionally, it has been identified as one major physiological barriers to effective delivery drugs solid its targeting with use pharmaceutical agents shown decompress blood vessels, thus improve perfusion efficacy cytotoxic drugs. In this study, we investigated contribution hyaluronan accumulation forces tumors. Using experimental data from two orthotopic breast models treating clinically approved anti-fibrotic (tranilast pirfenidone), found that growth-induced, residual are associated content. Furthermore, characterization revealed a good correlation accumulated elastic modulus tissue. Our results provide important insights on mechano-pathology can be used for design therapeutic strategies target hyaluronan.