Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy

• DOI: 10.1371/journal.pone.0194225
• Publication Date: 2018-03-12T17:40:32Z
• Authors: Silvia Parolo; Luca Marchetti; Mario Lauria; Karla Misselbeck; Marie-Pier Scott-...; Laura Caberlotto; Corrado Priami
• Keywords: Proteome

Although the genetic basis of Duchenne muscular dystrophy has been known for almost thirty years, cellular and molecular mechanisms characterizing disease are not completely understood an efficacious treatment remains to be developed. In this study we analyzed proteomics data obtained with SomaLogic technology from blood serum a cohort patients matched healthy subjects. We developed workflow based on biomarker identification network-based pathway analysis that allowed us describe different deregulated pathways. addition muscle-related functions, identified other biological processes such as apoptosis, signaling in immune system neurotrophin significantly modulated compared controls. Moreover, our involvement FoxO transcription factors putative regulators On whole, provided global view involved decipherable proteome.