Structural and functional alterations in the brain during working memory in medication-naïve patients at clinical high-risk for psychosis

• DOI: 10.1371/journal.pone.0196289
• Publication Date: 2018-05-09T13:36:04Z
• Authors: Jens Gisselgård; Alexander V. Lebedev; Kathinka Dæhli Kurz; Inge Joa; Jan Olav Johannessen; Kolbjørn Brønnick
• Keywords: Grey matter; Posterior cingulate

Several previous studies suggest that clinical high risk for psychosis (CHR) is associated with prefrontal functional abnormalities and more widespread reduced grey matter in prefrontal, temporal parietal areas. We investigated neural correlates to CHR medication-naïve patients. 41 patients 37 healthy controls were examined 1.5 Tesla MRI, yielding scans while performing an N-back task structural T1-weighted brain images. Functional data underwent automated preprocessing steps SPM Freesurfer, correspondingly. The groups compared employing mass-univariate strategy within the generalized linear modelling framework. demonstrated suppression of medial lobe (MTL) regions during n-back task. also found that, consistent findings, subjects thinning cingulate, insular inferior areas, as well hippocampal volumes. present findings add growing evidence specific potential neuroimaging markers vulnerability.