Genetic variation in the CLOCK gene is associated with idiopathic recurrent spontaneous abortion

• DOI: 10.1371/journal.pone.0196345
• Publication Date: 2018-05-16T13:36:07Z
• Authors: Alenka Hodžić; Polona Lavtar; Momčilo Ristanović; Ivana Novaković; Jelena Dotlić; Borut Peterlin
• Keywords: 2. Zero hunger; 0301 basic medicine; Abortion, Habitual; Models, Genetic; Science; Q; Slovenia; R; CLOCK Proteins; Polymorphism, Single Nucleotide; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Gene Frequency; Pregnancy; Risk Factors; Case-Control Studies; Medicine; Humans; Female; Serbia; Genetic Association Studies; Research Article; Genes, Dominant

Physiological studies in animals and human support an important role of circadian system reproduction. The aim this study was to investigate the potential association CLOCK gene polymorphisms with idiopathic recurrent spontaneous abortion (IRSA). We performed a case-control study. group consisted 268 women history three or more abortions 284 at least two live births no pathologic pregnancies all from Slovenia Serbia. Two SNPs were chosen genotyped. results showed statistically significant difference genotype distribution between groups for rs6850524 rs11932595. Our analysis that G allele under dominant model (GG+GC/CC) (p = 2∙10-4, OR 2.28, 95%CI 1.46-3.56) as well (GA+AA/AA) rs11932595 0.04, 1.47, 1.01-2.04) might be risk factors against IRSA. data suggest genetic variability is associated IRSA warranting further confirmation mechanistic investigations.