Genetic variation in the CLOCK gene is associated with idiopathic recurrent spontaneous abortion
2. Zero hunger
0301 basic medicine
Abortion, Habitual
Models, Genetic
Science
Q
Slovenia
R
CLOCK Proteins
Polymorphism, Single Nucleotide
3. Good health
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Pregnancy
Risk Factors
Case-Control Studies
Medicine
Humans
Female
Serbia
Genetic Association Studies
Research Article
Genes, Dominant
DOI:
10.1371/journal.pone.0196345
Publication Date:
2018-05-16T13:36:07Z
AUTHORS (6)
ABSTRACT
Physiological studies in animals and human support an important role of circadian system reproduction. The aim this study was to investigate the potential association CLOCK gene polymorphisms with idiopathic recurrent spontaneous abortion (IRSA). We performed a case-control study. group consisted 268 women history three or more abortions 284 at least two live births no pathologic pregnancies all from Slovenia Serbia. Two SNPs were chosen genotyped. results showed statistically significant difference genotype distribution between groups for rs6850524 rs11932595. Our analysis that G allele under dominant model (GG+GC/CC) (p = 2∙10-4, OR 2.28, 95%CI 1.46-3.56) as well (GA+AA/AA) rs11932595 0.04, 1.47, 1.01-2.04) might be risk factors against IRSA. data suggest genetic variability is associated IRSA warranting further confirmation mechanistic investigations.
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