The IL7RA rs6897932 polymorphism is associated with progression of liver fibrosis in patients with chronic hepatitis C: Repeated measurements design

• DOI: 10.1371/journal.pone.0197115
• Publication Date: 2018-05-09T13:42:13Z
• Authors: María Ángeles Jim...; Ana Zaida Gómez-M...; Daniel Pineda-Tenor; Luz Maria Medrano; Juan José Sánchez...; Amanda Fernández-...; Tomas Artaza-Varasa; José Saura-Montalbán; Sonia Vázquez-Morón; Pablo Ryan; Salvador Resino
• Keywords: Hepatitis C

The polymorphisms at the α-chain of IL-7 receptor (IL7RA) have been related to T-cell homeostasis and development may contribute immune system deregulation. In present study, we analyzed association between IL7RA progression liver fibrosis in patients infected with HCV. We carried out a retrospective study design consisting repeated measurements 187 HCV-infected patients, risk prediction using genetic factors. genotyped rs6897932, rs987106 rs3194051 Agena Bioscience's MassARRAY. Transient elastography was used measure stiffness. cut-offs were: <7.1 kPa (F0-F1), 7.1–9.4 (F2; significant fibrosis), 9.5-12.4 (F3; advanced ≥12.5 (F4; cirrhosis). All HCV genotypes were analyzed. median follow-up time 47.9 months. Baseline stiffness measurement (LSM) values did not show statistical differences for (p>0.05). univariate analysis, rs6897932 T allele had positive relationship an increase LSM (arithmetic mean ratio (AMR) = 1.21 (95%CI 1.08; 1.36); p 0.001), (F≥3) (odds (OR) 2.51 1.29; 4.88); 0.006) cirrhosis (F4) (OR 2.71 0.94; 5.03); 0.069). multivariable higher during (adjusted AMR 1.27 1.13; 1.42); p<0.001) odds [adjusted OR 4.46 1.87; 10.62); 0.001], 3.92 1.30; 11.77); 0.015]. Regarding polymorphisms, find results except 1.12 1.02; 1.23); polymorphism seems be increased patients. Thus, could physiopathology CHC might successfully stratify progression.