Evaluation of a novel non-invasive preimplantation genetic screening approach

• DOI: 10.1371/journal.pone.0197262
• Publication Date: 2018-05-10T13:38:25Z
• Authors: Valeriy Kuznyetsov; Svetlana Madjunkova; Ran Antes; Rina Abramov; Gelareh Motamedi; Zenon Ibarrientos; Clifford Librach
• Keywords: 0301 basic medicine; Science; Q; R; DNA; Fertilization in Vitro; Sequence Analysis, DNA; Aneuploidy; Proof of Concept Study; 3. Good health; Embryo Culture Techniques; 03 medical and health sciences; Blastocyst; Culture Media, Conditioned; Medicine; Humans; Genetic Testing; Preimplantation Diagnosis; Research Article

To assess whether embryonic DNA isolated from blastocyst culture conditioned medium (BCCM) combined with blastocoel fluid (BF) could be used for stage non-invasive preimplantation genetic testing chromosomal aneuploidy (non-invasive screening, NIPGS).