Preoperative prediction of microvascular invasion of hepatocellular carcinoma with IVIM diffusion-weighted MR imaging and Gd-EOB-DTPA-enhanced MR imaging

• DOI: 10.1371/journal.pone.0197488
• Publication Date: 2018-05-17T17:34:47Z
• Authors: Wei Zhao; Wenguang Liu; Huaping Liu; Xiaoping Yi; Jiale Hou; Yigang Pei; Hui Liu; Deyun Feng; Liyu Liu; Wenzheng Li
• Keywords: Intravoxel incoherent motion; HCCS

Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis hepatocellular carcinoma (HCC). The presence MVI in HCCs was evaluated on basis pathological reports surgical specimens defined tumor within a vascular space lined by endothelium that visible only microscopy. aim study to investigate usefulness intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging predicting HCC. Preoperative IVIM DW Gd-EOB-DTPA-enhanced MRI (DCE-MRI) 51 patients were analyzed. Standard apparent coefficient (ADC), D (the true coefficient), D* pseudodiffusion coefficient) f perfusion fraction), relative enhancement (RE) radiological features Univariate analysis revealed with had higher portion an irregular shape than without (p = 0.009), ADC, value significantly lower 0.022, p 0.007, respectively). Multivariate 0.012) ≤ 1.16×10-3mm2/sec 0.048) predictors MVI. Combining two value, sensitivity 94.4% specificity 63.6% obtained. In conclusion, we found may suggest HCCs.