Objective assessment of flap volume changes and aesthetic results after adjuvant radiation therapy in patients undergoing immediate autologous breast reconstruction

• DOI: 10.1371/journal.pone.0197615
• Publication Date: 2018-05-21T18:30:10Z
• Authors: Yujin Myung; Yousung Son; Tae-hyun Nam; Eunyoung Kang; Eun-Kyu Kim; In Ah Kim; Keun-Yong Eom; Chan Yeong Heo; Jae Hoon Jeong
• Keywords: Adult; Science; Mammaplasty; Q; R; Breast Neoplasms; Middle Aged; Combined Modality Therapy; Surgical Flaps; 3. Good health; 03 medical and health sciences; Imaging, Three-Dimensional; Treatment Outcome; 0302 clinical medicine; Case-Control Studies; Medicine; Humans; Female; Radiotherapy, Adjuvant; Tomography, X-Ray Computed; Mastectomy; Research Article

The use of immediate breast reconstruction and adjuvant radiation therapy is increasing in breast cancer patients. This study aimed to analyze the aesthetic outcome and changes in flap volume in patients with breast cancer undergoing radiation therapy of the surgical site after immediate autologous tissue reconstruction.Immediate abdominal free flap breast reconstruction following unilateral mastectomy was performed in 42 patients; 21 patients received adjuvant radiation (study group) and 21 patients did not (control group). To compare flap volume, three-dimensional computed tomography (CT) was performed before and after radiation. Also, aesthetic analysis was performed in both groups to evaluate shape changes.There was a 12.3% flap volume reduction after the completion of radiation in the experimental group that was significantly greater than the 2.6% volume reduction observed in the non-radiation group (P<0.01). There was no significant difference in the short- and long-term aesthetic results between the groups.When performing immediate autologous breast reconstruction, 14% volume overcorrection is recommended for patients in whom adjuvant radiation therapy is anticipated to improve aesthetic outcomes.