The different course of alcoholic and idiopathic chronic pancreatitis: A long-term study of 2,037 patients

• DOI: 10.1371/journal.pone.0198365
• Publication Date: 2018-06-08T17:31:20Z
• Authors: Lu Hao; Li-Sheng Wang; Yu Liu; Teng Wang; Hong-Lei Guo; Jun Pan; Dan Wang; Ya-Wei Bi; Jun-Tao Ji; Lei Xin; Ting-Ting Du; Jin-Huan Lin; Di Zhang; Xiang-Peng Zeng; Wen-Bin Zou; Hui Chen; Ting Xie; Bai-Rong Li; Zhuan Liao; Zhi-Jie Cong; Zheng-Lei Xu; Zhao-Shen Li; Liang-Hao Hu
• Keywords: Pancreatitis, chronic; Chronic alcoholic

Background Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare natural course alcoholic (ACP) and idiopathic (ICP). Methods CP patients admitted our center from January 2000 December 2013 were enrolled. Characteristics compared between ACP ICP patients. Cumulative rates diabetes mellitus (DM), steatorrhea, pancreatic stone, pseudocyst, biliary stricture, cancer after onset diagnosis calculated, respectively. The cumulative DM steatorrhea stone also calculated. Results A total 2,037 Among them, 19.8% (404/2,037) 80.2% (1,633/2,037) differs in many aspects, especially gender, age, smoking, complications, morphology duct, type pain. development DM, PPC, stricture significantly earlier more common No significant difference was observed for development. There rather close correlation exocrine/endocrine insufficiency patients, which much less correlated Conclusion long-term profile some important aspects. usually have severe CP. These differences should be recognized treatment