B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses

• DOI: 10.1371/journal.pone.0199034
• Publication Date: 2018-07-05T17:31:53Z
• Authors: Renata Ariza Marq...; Noely Paula Crist...; Kaori Yokochi; Maria Beatriz Sar...; Luciana Benevides; Paulo Francisco R...; Edmund Chada Baracat; Jesus Paula Carvalho; Luisa Lina Villa; Ana Paula Lepique
• Keywords: CD80; CD86

Immune evasion by tumors includes several different mechanisms, including the inefficiency of antigen presenting cells (APCs) to trigger anti-tumor T cell responses. B lymphocytes may display a pro-tumoral role but can also be modulated function as lymphocytes, capable triggering anti-cancer immune While dendritic cells, DCs, are best APC population activate naive DCs or their precursors, monocytes, frequently tumors, displaying tolerogenic phenotype in cancer patients. In patients with cervical cancer, we observed that monocyte derived tolerogenic, inhibiting allogeneic activation compared same obtained from precursor lesions cervicitis. this work, show respond treatment sCD40L and IL-4 increasing CD80+CD86+ population, therefore potentially ability cells. To test if could actually responses, designed an experimental model where harvested tumor bearing donors, after stimulation, transplanted them, together into RAG1-/- recipients, previously injected We were able anti-CD40 activated secondary dependent on MHC-II expression. Moreover, showed resistant unable stimulate summary, our results suggest used tool for immunotherapy against cancer.