Exploring the association between thyroid- stimulating hormone and metabolic syndrome: A large population-based study

• DOI: 10.1371/journal.pone.0199209
• Publication Date: 2018-06-21T13:51:50Z
• Authors: Yi-Chao Zhou; Wen-Hui Fang; Tung-Wei Kao; Chung-Ching Wang; Yaw-Wen Chang; Tao-Chun Peng; Chen-Jung Wu; Hui-Fang Yang; James Yi-Hsin Chan; Wei-Liang Chen
• Keywords: Prediabetes; Quartile; Longitudinal Study; Thyroid-stimulating hormone; Cross-sectional study

A growing amount of evidence suggests that thyroid-stimulating hormone (TSH) is associated with cardiometabolic risk. However, there have been few longitudinal studies. The aim this study was to explore the causal relationship between TSH and metabolic syndrome (MetS) in a large population-based study. From 2010 2016 at Health Management Center Tri-Service General Hospital, 25,121 eligible patients were enrolled our cross-sectional analyses. Cox proportional hazard models used investigate association among hypertension (HTN), prediabetes (pre-DM), MetS, diabetes (DM) levels (N = 12,463). average follow-up time 7.2 years. In analysis, OR for MetS 1.06 (95% CI 1.03-1.09; P< 0.05), while ORs DM, pre-DM or HTN not statistically significant (all P> 0.05). After dividing into four quartiles, presence determined by comparing highest quartile lowest 1.37 1.18-1.60), 1.42 1.20-1.67), 1.44 1.22-1.69) (all, P<0.05) model 1, 2 3 respectively. HR incidence 1.33 1.17-1.51; P < Our revealed had strong incident MetS.