Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes

• DOI: 10.1371/journal.pone.0201535
• Publication Date: 2018-08-02T14:31:05Z
• Authors: Megumi Oshima; Tadashi Toyama; Masakazu Haneda; Kengo Furuichi; Tetsuya Babazono; Hiroki Yokoyama; Kunitoshi Iseki; Shinichi Araki; Toshiharu Ninomiya; Shigeko Hara; Yoshiki Suzuki; Masayuki Iwano; Eiji Kusano; Tatsumi Moriya; Hiroaki Satoh; Hiroyuki Nakamura; Miho Shimizu; Akinori Hara; Hirofumi Makino; Takashi Wada
• Keywords: Adult; Male; Science; Q; R; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Risk Factors; Prevalence; Medicine; Albuminuria; Humans; Kidney Failure, Chronic; Female; Research Article; Aged; Follow-Up Studies; Glomerular Filtration Rate

According to studies by the National Kidney Foundation and Food Drug Administration, 30% 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, benefits using these diabetic patients remain unclear.This cohort study comprised Japanese with type 2 diabetes; those repeated serum creatinine measurements during a baseline period years (n = 1868) or 3 2001) were enrolled. Subsequent risks ESRD following eGFR assessed.In 2-year analysis, cumulative prevalence -20%, -30%, -40%, -53% changes 23.9%, 11.1%, 6.8%, 3.7%, respectively. There 133 cases (7.1%) subsequent median follow-up 6.5 years. In 3-year corresponding proportions 28.1%, 14.0%, 7.7%, 3.9%, respectively, 110 participants (5.5%) reaching 5.5 The adjusted hazard ratios -53%, -20% 22.9 (11.1-47.3), 12.8 (6.9-23.7), 8.2 (4.3-15.5), 3.9 (2.2-7.0), respectively when compared no eGFR. 29.7 (10.8-81.9), 18.4 (7.6-44.7), (5.2-32.2), 5.4 (2.3-12.8), subgroup similar trends observed macroalbuminuria at baseline.Declines strongly associated risk patients. addition declines, 20% decline over considered candidate endpoint kidney disease.