Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes

Adult Male Science Q R Middle Aged 3. Good health 03 medical and health sciences 0302 clinical medicine Diabetes Mellitus, Type 2 Risk Factors Prevalence Medicine Albuminuria Humans Kidney Failure, Chronic Female Research Article Aged Follow-Up Studies Glomerular Filtration Rate
DOI: 10.1371/journal.pone.0201535 Publication Date: 2018-08-02T14:31:05Z
ABSTRACT
According to studies by the National Kidney Foundation and Food Drug Administration, 30% 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, benefits using these diabetic patients remain unclear.This cohort study comprised Japanese with type 2 diabetes; those repeated serum creatinine measurements during a baseline period years (n = 1868) or 3 2001) were enrolled. Subsequent risks ESRD following eGFR assessed.In 2-year analysis, cumulative prevalence -20%, -30%, -40%, -53% changes 23.9%, 11.1%, 6.8%, 3.7%, respectively. There 133 cases (7.1%) subsequent median follow-up 6.5 years. In 3-year corresponding proportions 28.1%, 14.0%, 7.7%, 3.9%, respectively, 110 participants (5.5%) reaching 5.5 The adjusted hazard ratios -53%, -20% 22.9 (11.1-47.3), 12.8 (6.9-23.7), 8.2 (4.3-15.5), 3.9 (2.2-7.0), respectively when compared no eGFR. 29.7 (10.8-81.9), 18.4 (7.6-44.7), (5.2-32.2), 5.4 (2.3-12.8), subgroup similar trends observed macroalbuminuria at baseline.Declines strongly associated risk patients. addition declines, 20% decline over considered candidate endpoint kidney disease.
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