Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans

• DOI: 10.1371/journal.pone.0201568
• Publication Date: 2018-08-13T13:27:17Z
• Authors: Anny H. Xiang; Mary Helen Black; Yu-Hsiang Shu; Jun Wu; Adrienne MacKay; Corinna Koebnick; Richard M. Watanabe; Thomas A. Buchanan
• Keywords: Adult; Male; 2. Zero hunger; Science; Q; R; Glucose Tolerance Test; Weight Gain; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Adipokines; Insulin-Secreting Cells; Mexican Americans; Medicine; Humans; Female; Longitudinal Studies; Obesity; Insulin Resistance; Research Article

Obesity and adipokines are associated with development of type 2 diabetes. However, limited longitudinal studies have examined their roles on declining β-cell function over time. This report assessed three adiposity measures (BMI, percent body fat, trunk fat), insulin resistance, fifteen in relationship to change measured by disposition index (DI) from frequently-sampled-intravenous-glucose-tolerance testing. The results showed that factors were significantly independently rate DI time: BMI (negative), IL-6 baseline adiponectin (positive). association was the strongest for changing largely explained resistance; also resistance. Baseline remained positively after adjustment suggesting an independent effect preserve or improve function. These findings provide evidence potential mechanisms role obesity promoting dysfunction, highlighting importance mitigating its metabolic effects preventing treating