Renal function and anemia in relation to short- and long-term prognosis of patients with acute heart failure in the period 1985-2008: A clinical cohort study

• DOI: 10.1371/journal.pone.0201714
• Publication Date: 2018-08-07T13:51:06Z
• Authors: Jan C. van den Berge; Alina A. Constant...; Ron T. van Domburg; Milos Brankovic; Jaap W. Deckers; K. Martijn Akkerhuis
• Keywords: Heart Failure; Male; Time Factors; Science; Q; R; Anemia; Middle Aged; Kidney; Prognosis; 3. Good health; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Acute Disease; Medicine; Humans; Female; EMC COEUR-09; Research Article; Aged

Background Renal dysfunction and anaemia are common in patients with acute heart failure (HF). It is not known whether their combined presence has additive prognostic value. We investigated value separately combination, on prognosis HF patients. Furthermore, we examined the improvement was comparable between without renal dysfunction. Methods results This prospective registry includes 1783 admitted to (Intensive) Coronary Care Unit for period of 1985–2008. The outcome measure composite all-cause mortality, transplantation left ventricular assist device implantation. In dysfunction, anemia associated worse 30-day (HR 2.91; [95% CI 1.69–5.00]), but 10-year 1.13 0.93–1.37]). On contrary, found influence both at 30 days 1.93 1.33–2.80]) 10 years 1.27 1.10–1.47]). Over time, survival rate improved preserved function 0.73 0.55–0.97]), Conclusion long-term a have significantly. However, did change. Anemia strong prognosticator short-term all also impaired prognosis.