Duration and dosing of Proton Pump Inhibitors associated with high incidence of chronic kidney disease in population-based cohort

• DOI: 10.1371/journal.pone.0204231
• Publication Date: 2018-10-17T18:03:23Z
• Authors: Antonio Rodríguez...; Maria A. Barceló; Marc Saez; Gabriel Coll-de-T...
• Keywords: Adult; Male; Adolescent; Ronyons -- Malalties; Science; Kidneys -- Diseases; Drug Administration Schedule; Cohort Studies; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Humans; Drug Dosage Calculations; Renal Insufficiency, Chronic; Aged; Retrospective Studies; Incidence; Q; R; Proton Pump Inhibitors; Middle Aged; 3. Good health; Medicine; Female; Research Article; Glomerular Filtration Rate

Background Proton Pump Inhibitors (PPIs) have been associated with chronic kidney disease (CKD). Our objective was to quantify the association between PPI use and incident CKD in a population-based cohort. Methods findings We used retrospective cohort, including people aged 15 years or over, January 1, 2005 December 31, 2012. measured follow-up session by recording prescriptions. Incident defined as an estimated glomerular filtration rate < 60 ml/ min/1.73 m2 and/or urinary albumin level creatinine ≥ 30 mg/g, two more determinations over period of at least 3 months follow-up. Inhibitor analysis adjusted for different clinical variables (Hazard Ratio (HR) 1.18; 95% CI 1.04–1.51) individuals who basal visit (HR 1.37; 1.25–1.50) those started during High doses increased risk 1.92; 95%CI 1.00–6.19) any type exposure PPIs 2.40; 1.65–3.46) high throughout This after three months' PPIs, (HR1.78; 1.39–2.25) third sixth 1.30; 1.07–1.72) month. Conclusions is higher CKD. greater becomes apparent exposure.