Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications

• DOI: 10.1371/journal.pone.0209948
• Publication Date: 2019-03-20T18:27:18Z
• Authors: S. Shanmugasundar; N. Kannan; E. Sundaravadivel; Sarang Zsolt; K. S. Mukunthan; J. Manokaran; J. Narendranath; V. P. Kamalakannan; P. Kavitha; V. Prabhu; N. Balasubramanian
• Keywords: Cell Survival; Surface Properties; Science; 02 engineering and technology; Nanocomposites; Mice; 03 medical and health sciences; Drug Delivery Systems; 0302 clinical medicine; Materials Testing; Spectroscopy, Fourier Transform Infrared; Animals; Polymethyl Methacrylate; Q; R; Bone Cements; Membranes, Artificial; Silicon Dioxide; RAW 264.7 Cells; Microscopy, Electron, Scanning; Medicine; Polystyrenes; 0210 nano-technology; Research Article

Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acrylate/polystyrene/silica composite membrane. Methods The characteristic of the composite was investigated through modern state art of instrumentation. Results The functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum confirm that the blend was mixed thoroughly and the formation of unite intimately between the polymers. The membranes were observed by SEM for its surface homogeneity which depends upon the composition of the two blending polymers. The captured SEM images showed the formation of microcracks on the surface, which was evidently controlled by varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of PMMA/PS/Si displayed higher water uptake compared to other blended membranes. The composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed that all the samples exhibited excellent cell viability. Conclusion The inflammatory response of composite with equal concentration of PMMA-PS were performed and observed no inflammation in comparison with control and other tested concentrations.