Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

• DOI: 10.1371/journal.pone.0210320
• Publication Date: 2019-01-18T18:24:09Z
• Authors: Andrea Silvestrini; Carmine Bruno; Edoardo Vergani; Angela Venuti; Angela Maria Rita...; Francesco Guidi; Nicola Nicolotti; Elisabetta Meucci; Alvaro Mordente; Antonio Mancini
• Keywords: Myokine; Pathophysiology

Irisin, a recently discovered myokine, has been considered prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin patients with heart failure (HF), both preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated circulating levels HFpEF and HFrEF patients, correlating them metabolic parameters total antioxidant capacity (TAC), as index oxidative stress. Irisin was significantly higher than (7.72 ± 0.76 vs 2.77 0.77 ng/ml, respectively). An inverse correlation between TAC found HFpEF, but not HFrEF. Conversely, present HOMA index. These support hypothesis that different pathophysiological mechanism is involved two HF subtypes, stress modulates secretion.