Multidisciplinary approach is associated with improved survival of hepatocellular carcinoma patients

• DOI: 10.1371/journal.pone.0210730
• Publication Date: 2019-01-14T18:34:28Z
• Authors: Dong Hyun Sinn; Gyu-Seong Choi; Hee Chul Park; Jong Man Kim; Honsoul Kim; Kyoung Doo Song; Tae Wook Kang; Min Woo Lee; Hyunchul Rhim; Dongho Hyun; Sung Ki Cho; Sung Wook Shin; Woo Kyoung Jeong; Seong Hyun Kim; Jeong Il Yu; Sang Yun Ha; Su Jin Lee; Ho Yeong Lim; Kyunga Kim; Joong Hyun Ahn; Wonseok Kang; Geum-Youn Gwak; Yong-Han Paik; Moon Seok Choi; Joon Hyeok Lee; Kwang Cheol Koh; Jae-Won Joh; Hyo Keun Lim; Seung Woon Paik
• Keywords: Fetal Proteins; Male; Carcinoma, Hepatocellular; Science; Q; Liver Neoplasms; R; Kaplan-Meier Estimate; Middle Aged; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; ROC Curve; Medicine; Humans; Female; Research Article; Aged; Proportional Hazards Models; Retrospective Studies

Given the complexity of managing hepatocellular carcinoma (HCC), a multidisciplinary approach (MDT) is recommended to optimize management HCC patients. However, evidence suggesting that MDT improves patient outcome limited.We performed retrospective cohort study all patients newly-diagnosed with between 2005 and 2013 (n = 6,619). The overall survival (OS) rates who were not managed via compared in entire 6,619), exactly matched 1,396).In cohort, 5-year rate was significantly higher (71.2% vs. 49.4%, P < 0.001), an adjusted hazard ratio (HR) 0.47 (95% confidence interval [CI]; 0.41-0.53). In (71.4% 58.7%, 0.001; HR [95% CI] 0.67 [0.56-0.80]). benefit observed most pre-defined subgroups, especially significant poor liver function (ALBI grade 2 or 3), intermediate advanced tumor stage (BCLC B C), high alphafetoprotein levels (≥200 ng/ml).MDT associated improved patients, indicating can be valuable option improve This warrants prospective evaluations.