Early increased neutrophil-to-lymphocyte ratio is associated with poor 3-month outcomes in spontaneous intracerebral hemorrhage

• DOI: 10.1371/journal.pone.0211833
• Publication Date: 2019-02-07T20:29:46Z
• Authors: Jie Qin; Zhu Li; Guangming Gong; Hongwei Li; Ling Chen; Bo Song; Xinjing Liu; Changhe Shi; Jing Yang; Ting Yang; Yuming Xu
• Keywords: Adult; Male; Adolescent; Neutrophils; Science; Q; R; Middle Aged; Disease-Free Survival; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Medicine; Humans; Female; Lymphocyte Count; Lymphocytes; Research Article; Cerebral Hemorrhage; Retrospective Studies

The aim of this study was to evaluate the association dynamic neutrophil-to-lymphocyte ratio (NLR) with 3-month functional outcomes in patients sICH. We retrospectively identified 213 consecutive sICH hospitalized First Affiliated Hospital Zhengzhou University from January 2017 May 2018. Patients were divided into independence (FI) or unfavorable prognosis (UP) groups based on outcomes. Admission leukocyte counts within 24 hours symptom onset obtained, and recorded fraction, which numerator is neutrophil denominator lymphocyte, as NLR0. Determined NLR1, NLR3, NLR7, NLR14 day 1 (n = 77), 3 126), 7 123), 14 105), respectively. relationships between NLR clinical features evaluated using Spearman's Kendall's correlation analysis. Logistic regression analyses used identify risk factors for prognosis. patients' positively associated National Institutes Health Stroke Scale, ICH score, hematoma volume at admission, while inversely correlated GCS score FI follow-up. Furthermore, higher lower absolute lymphocyte count obtained admission independently factor UP months (adjusted odds [OR]: 1.06, 95% confidence interval [CI]: 1.003, 1.12; OR: 0.41, CI: 0.18, 0.94, respectively). In conclusion, early stages predictive patients.