Prevalence and predictors for sustained remission in rheumatoid arthritis

• DOI: 10.1371/journal.pone.0214981
• Publication Date: 2019-04-19T17:32:07Z
• Authors: Yoon-Kyoung Sung; Kazuki Yoshida; Femke H. M. Prince; Michelle L. Frits; Soo-Kyung Cho; Jung-Yoon Choe; Hye-Soon Lee; Jisoo Lee; Shin-Seok Lee; Dae-Hyun Yoo; Simon M. Helfgott; Nancy A. Shadick; Michael E. Weinblatt; Daniel H. Solomon; Sang-Cheol Bae
• Keywords: EMC MM-04-54-08-A; Male; Science; Q; Remission Induction; R; Middle Aged; 12. Responsible consumption; 3. Good health; Arthritis, Rheumatoid; 03 medical and health sciences; 0302 clinical medicine; Republic of Korea; Prevalence; Medicine; Humans; Female; Prospective Studies; Research Article; Aged; Follow-Up Studies

Objective Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little known about predictors for patients reaching Using two independent cohorts, we aimed to evaluate prevalence and Methods The study cohort consisted subjects RA from Brigham Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) Korean Observational Network (KORONA). We analyzed who reached 2009 follow up data consecutive years. was defined by Disease Activity Score 28- (DAS28-CRP) less than 2.6. Sustained three annual visits Predictors were identified multivariate logistic regression analysis. Results A total 465 2009. achieved 53 92 (57.5%) BRASS 198 373 (53.1%) KORONA. In analyses, baseline were: disease duration 5 years [odds ratio (OR) 1.96, 95% confidence interval (95% CI) 1.08–3.58], Modified Health Assessment Questionnaire (MHAQ) score 0 (OR 1.80, CI 1.18–2.74), non-use oral glucocorticoid 1.58, 1.01–2.47). Conclusion More half remained through 2011. Short duration, no disability, at associated