Large cortical bone pores in the tibia are associated with proximal femur strength

• DOI: 10.1371/journal.pone.0215405
• Publication Date: 2019-04-17T18:08:11Z
• Authors: Gianluca Iori; Johannes Schneider; Andreas Reisinger; Frans Heyer; Laura Peralta; Caroline Wyers; Melanie Gräsel; Reinhard Barkmann; Claus C. Glüer; J. P. van den Bergh; Dieter Pahr; Kay Raum
• Keywords: Hip Fracture; X-ray microtomography

Alterations of structure and density cortical bone are associated with fragility fractures can be assessed in vivo humans at the tibia. Bone remodeling deficits aging women have been recently linked to an increase size pores. In this ex study, we characterized microarchitecture 19 tibiae from human donors (aged 69 94 years) address, whether reflect impairments mechanical competence proximal femur, i.e., a major fracture site osteoporosis. Scanning acoustic microscopy (12 μm pixel size) provided reference microstructural measurements left tibia, while vBMD was obtained using microcomputed tomography (microCT). The areal mineral both right femoral necks (aBMDneck) measured by dual‐energy X‐ray absorptiometry (DXA), homogenized nonlinear finite element models based on high-resolution peripheral quantitative computed hip stiffness strength for one-legged standing sideways falling loads. Hip aBMDneck (r = 0.74 0.78), tibial thickness 0.81) cross-sectional geometry 0.48 0.73) same leg. Tibial only loads 0.59 0.65). Cortical porosity (Ct.Po) tibia not any parameters. However, proportion Ct.Po attributable large pores (diameter > 100 μm) -0.61) 0.48) conditions. When added aBMDneck, prevalence could explain up 17% femur ultimate force. conclusion, characteristics as well DXA, but it remains tested such properties vivo.